LASIGE

LASIGE is a research unit at the Faculty of Sciences of the University of Lisbon, in the field of Computer Science and Engineering. LASIGE gathers experts from several areas of the computing field, including artificial intelligence, machine learning, concurrency, distributed computing, embedded and cyber-physical systems, human-centred computing, information systems, information retrieval, security and privacy, software validation and verification, theory of computing, with an emphasis on computational complexity, and applied computing to life and medical sciences. LASIGE’s activities are organised around seven lines of excellence supported by key quality indicators.

Cyber‐Physical Systems

The LASIGE research line Cyber-Physical Systems (CPS) investigates the functional, human, trustworthiness and timing aspects of cyber-physical systems. This research line focuses on system solutions for offline verification and online monitoring of security- and safety-critical embedded real-time systems, mechanisms for efficient and adaptive interactions among entities in specific scenarios, protocols for autonomous driving scenarios, and visual analytics techniques and tools for exploring heterogeneous datasets from cyber-physical and smart systems, making them more transparent to end-users.

Data and Systems Intelligence

The research line on Data and Systems Intelligence (DSI) strives to devise innovative solutions for large‐scale data problems and complex systems. DSI intersects areas of recent high visibility and impact, such as machine learning and data mining, but also the general fields of artificial intelligence. This highly multidisciplinary research line aims at advancing research and knowledge in the recent flagship application and research domain of data science, web science, and network science.

Dependable and Secure Decentralized Systems

Dependable and Secure Decentralized Systems (DS2) investigates models, protocols and architectures that are suitable for applications with strong dependability requirements, namely applications that need to remain operational despite accidental faults or malicious attacks. The solutions being developed cover a diverse set of objectives, enforcing the prevention, detection and tolerance of failures. The kind of environments that are being contemplated include cloud deployments, highly dynamic and geographically distributed networks, mobile distributed computing, web systems and applications, smart grids and other critical infrastructures.

Health and Biomedical Informatics

LASIGE presents a longstanding record of research contributions in the area of Health & Biomedical Informatics (HBI), by providing innovative solutions for processing biological and medical data, and for supporting the discovery of new biomedical insights. This research line aims to encompass all the scientific work in LASIGE where informatics plays a fundamental role in creating new knowledge in life and health sciences.

Inclusive Human-Computer Interaction

LASIGE presents a longstanding record of research contributions in the area of accessible computing, in assessing, designing, and developing technologies for people with different abilities. The Inclusive Human-Computer Interaction (IHCI) research line gathers all the contributions that seek to evaluate or design interfaces for people with disabilities, older adults, or people suffering from situational impairments.

Reliable Software Systems

Reliable Software Systems (RSS) focuses on modelling techniques and formal analysis approaches to software system structure and behaviour. It aims at enhancing the software engineering practice and particularly the quality of the software.
Its activity ranges from developing theoretical models, languages and techniques to the development of tools that can be used in the real-world software development process, with a clear impact on the workflow of developers and the industry in general. RSS centers its attention on the verification and validation of software, increasing the confidence of developers in their code, especially in complex and error-prone scenarios, such as concurrent and distributed programs.

Theory of Computing

Theory of Computing (ToC) is dedicated to the foundational, theoretical study of computation: What is a computer? What is computation and where does it manifest? What are the capabilities and limitations of different kinds of computers? The method we use to study this question is the mathematical method: we use precise mathematical definitions to model various systems where computation (or a computation-like phenomenon) occurs, and then we use rigorous, deductive reasoning (i.e., mathematical proofs) to understand the behavior and properties of such systems.

RECENT

NEWS

LASIGE Researchers Take Virtual Reality to Palliative Care at Santa Casa da Misericórdia de Arganil

02/11/2026

Accepting the challenge from Santa Casa da Misericórdia de Arganil, a team of student researchers from LASIGE led by integrated researcher Tiago Guerreiro travelled up north in late May 2026 to deliver a half-day workshop on Virtual Reality (VR) in Healthcare, particularly in the context of palliative care. The initiative aimed to empower the professional […]

LASIGE researchers explore how different protein representations impact GNN-based protein-protein interaction prediction

30/10/2026

LASIGE researchers Laura Balbi, Rita Sousa, Pedro Cotovio, and Cátia Pesquita published a new study, titled “The role of protein embeddings for protein-protein interaction prediction with graph neural networks”, in Briefings in Bioinformatics (Top 10% journal according to Scimago, Scopus and Web of Science rankings). The paper investigates how different protein representations can improve protein-protein […]

Leveraging Adversarial AI to Defend Cyber-Physical Systems Against Covert Attacks

28/10/2026

LASIGE integrated researchers Alan Oliveira de Sá (principal investigator) and José Cecílio, together with Gonçalo Fernandes (MSc student), are developing ASTERICS – Adversarial Strategies for counTERing Intelligent CyberattackS, a project funded through the LASIGE/FCT Seed Projects Call 2025. ASTERICS investigates innovative cybersecurity strategies to counter intelligent attacks that leverage Artificial Intelligence (AI) to learn the […]

RECENT

TALKS

CPS and DS2 Meetup | Alex Davidson

12/11/2026

LASIGE Talks: Catarina Gamboa and Manuel Piçarra

04/11/2026

LASIGE Welcome Day 2026

07/10/2026

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ONGOING

PROJECTS

CancerScan

CancerScan: Smart pathology slide scanner for diagnosis and patient-specific treatment recommendation in oncology

GoalballXR

Facilitating Onboarding and Training in Goalball with Extended Reality

IncGames

Modular Game Design for Inclusive Social Interactions

ChildrEngage

ChildrEngage: Measuring Real-Time Children Group Engagement

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Projects

PUBLICATIONS

Members

RECENT

PUBLICATIONS

Inês Gil, David Gonçalves, João Guerreiro, André Rodrigues. From Board to Screen and Back: Exploring Continuous Transmedial Play. Proceedings of the ACM on Human-Computer Interaction, 10(7):1-22, Association for Computing Machinery (ACM), 2026 [Biblius]

David Gonçalves, Daniel Reis, Kathrin Gerling, João Guerreiro, Tiago Guerreiro, André Rodrigues. Asymmetric Gaming Further Apart: Effects of World and Goal Sharing on Cooperative Play. Proceedings of the ACM on Human-Computer Interaction, 10(7):1-29, Association for Computing Machinery (ACM), 2026 [Biblius]

Nessrine Farhat, Pierre David, Leah Rifi, Nuno Garcia. Computer vision as a data source for digital twins in manufacturing: A Sim2Real pipeline. Journal of Industrial Information Integration, 54, Elsevier BV, 2026 [Biblius]

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SOFTWARE &

TOOLS

Datapark

A platform that enables subjective and objective data collection for Parkinson’s disease. Futhermore, improves data visualization for clinicians. Team @ LASIGE:...

BFT-SMaRt

BFT-SMaRt is a high-performance Byzantine fault-tolerant state machine replication library developed in Java with simplicity and robustness as primary requirements. Our...

ParTypes

ParTypes is a toolchain for validating and synthesising message-based programs for Message Passing Interface (MPI) programs. The general aim is to...

QualWeb engine

An automated web accessibility evaluation engine with support for WCAG 2.1 and ACT-Rules. Team @ LASIGE: João Vicente; António Estriga; Bruno...

CONFIDENT

CONFIDENT is a toolchain for effective construction and evolution of REST APIs. CONFIDENT aims at supporting all phases of RESTful software...

FreeST

A concurrent programming language, based on a core functional language with primitives to fork new threads, create channels and exchange messages...

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About LASIGE

LASIGE is a research and development unit at the Faculty of Sciences of the University of Lisbon, in the field of Computer Science and Engineering.

LASIGE has approximately 250 collaborators, including researchers holding a doctoral degree, PhD and MSc students and other junior researchers, project managers, and a team of system administrators. The current Director is Tiago Guerreiro.